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KMID : 1128320140120020055
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Electrolytes & Blood Pressure
2014 Volume.12 No. 2 p.55 ~ p.65
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Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies
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Oh Gi-Su
Kim Hyung-Jin
Ai Hua Shen
Lee Su-Bin
Dipendra Khadka
Arpana Pandit
So Hong-Seob
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Abstract
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Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory res-ponses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxi- city is still high, occurring in approximately one-third of patients who have under- gone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity.
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KEYWORD
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Cisplatin, Chemotherapy, Nephrotoxicity, NAD
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